Antiviral Nucleotides

Nucleoside Triphosphates | Antiviral Nucleotides

Antiviral nucleotides are nucleotide analogs that repress the viral reproduction by interfering with several key mechanisms of viral nucleic acid replication. They compete with natural dNTP/NTP substrates for the incorporation into the nascent viral nucleic acid thereby leading to chain termination or mutagenesis.

Antivirals are used to treat retroviruses such as HIV, tumors and cancer by blocking reverse transcriptase (Marchand et al.). They are also used to treat Hepatitis by blocking an RNA-dependent DNA polymerase (Walsh et al.). Antiviral nucleotides or virostatics repress viral reproduction as competitive substrate inhibitors or chain terminators. The analogue is incorporated into the viral DNA and prevents complete synthesis of the double-stranded viral DNA.

Marchand B, White KL, Ly JK, Margot NA, Wang R, McDermott M, Miller MD, Gφtte M. Effects of the translocation status of human immunodeficiency virus type 1 reverse transcriptase on the efficiency of excision of tenofovir. Antimicrob Agents Chemother. 2007 Aug;51(8):2911-9.

Walsh AW, Langley DR, Colonno RJ, Tenney DJ. Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir. PLoS One. 2010 Feb 12;5(2):e9195.

Product Family
Antiviral Nucleoside Monophosphates
Antiviral Nucleoside Triphosphates
Antiviral Nucleoside Monophosphates
Antiviral Nucleoside Triphosphates
Antiviral Nucleoside Monophosphates
Antiviral Nucleoside Triphosphates

Antiviral Nucleotides

Nucleoside Triphosphates currently in inventory and available for immediate shipment:

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