Biotin Nucleotide Analogs

Nucleoside Triphosphates | Biotin Nucleotide Analogs

Biotin nucleotide analogs with natural ribose or 2’ deoxyribose sugars, containing modifications in the base, have many applications. Biotin has strong affinity towards Avidin and streptavidin, which can be used in the capture or purification of the Biotin-labeled NTPs by binding to solid support. Other applications include hybrid capture, immunoassays, labeling and nucleic acid detection. Below is an example of hybrid capture as outlined by Wikipedia:

“In March 2003, the U.S. Food and Drug Administration (FDA) approved the Hybrid Capture 2 test manufactured by Qiagen/Digene, which is a 'hybrid-capture' test as an adjunct to Pap testing. The test may be performed during a routine Pap smear. It detects the DNA of 13 'high-risk' HPV types that most commonly affect the cervix, it does not determine the specific HPV types. Hybrid Capture 2 is the most widely studied commercially available HPV assay and the majority of the evidence for HPV primary testing in population based screening programs is based on the Hybrid Capture 2 assay.”

This modification comes either in the form of replacing purine and pyrimidine with similar heterocyclic structure or attachment of linker for the purpose of attaching labels for diagnostics. These Base Modified Nucleoside Triphosphates utilize Aminoallyl linkers, which can facilitate synthesis of labeled nucleoside triphosphates. ChemCyte has synthesized hundreds of base-modified NTPs for clients. We can utilize any desired linker to synthesize for this purpose.

Product Family
Biotin Deoxyribonucleoside Triphosphate Analogs
Biotin RibonucleosideTriphosphate Analogs

Biotin Nucleotide Analogs

Nucleoside Triphosphates currently in inventory and available for immediate shipment:

  • Non-Modified Nucleoside Triphosphates
      dATP, dCTP, dGTP, dITP, dUTP, TTP, ATP, CTP, GTP, UTP
  • Base Modified Nucleoside Triphosphates
      AA-dCTP, AA-dUTP, AA-CTP, AA-UTP, 8-Amino-ATP
  • Phosphate Modified Nucleoside Triphosphates
      Alpha-thio-dATP, Alpha-thio-dCTP, Alpha-thio-dGTP, Alpha-thio-TTP, Alpha-thio-ATP, Alpha-thio-CTP, Alpha-thio-GTP, Alpha-thio-UTP
  • Sugar Modified Nucleoside Triphosphates
      2’-Fluoro-dCTP, 2’-Fluoro-dUTP, ddATP, ddCTP, ddGTP, dTTP, ddUTP, 2'-O-Me-ATP, 2'-O-Me-CTP, 2'-O-Me-GTP, 2'-O-Me-UTP
  • Phosphate and Sugar Modified Nucleoside Triphosphates
      Alpha-thio-ddATP, Alpha-thio-ddCTP, Alpha-thio-ddGTP, Alpha-thio-dTTP
  • Biotin Nucleotide Analogs
      Biotin-5-dCTP, Biotin-11-dCTP, Biotin-16-dCTP, Biotin-5-dUTP, Biotin-11-dUTP, Biotin-16-dUTP, Biotin-5-CTP, Biotin-11-CTP, Biotin-16-CTP, Biotin-5-UTP, Biotin-11-UTP, Biotin-16-UTP
  • Cyanine Dye Nucleotide Analogs
      SulfoCyanine 3-dCTP, SulfoCyanine 3-dUTP, SulfoCyanine 5-dCTP, SulfoCyanine 5-dUTP, SulfoCyanine 3-CTP, SulfoCyanine 3-UTP, SulfoCyanine-5-CTP, SulfoCyanine-5-UTP
  • Antiviral Nucleotides
      3TCMP, 3TCTP, AzTMP, AzTTP, d4TMP, d4TTP, Ribavirin-5‘-triphosphate
  • Labeled Nucleoside Triphosphates
      Dye-Labeled-5-Aminoallyl-dUTP, Biotin Labeled-5-Aminoallyl-dUTP, Dye-Labeled-5-Aminoallyl-dCTP, Biotin Labeled-5-Aminoallyl-dCTP, Dye-Labeled-5-Aminoallyl-ddUTP, Biotin Labeled-5-Aminoallyl-ddUTP, Dye-Labeled-5-Aminoallyl-ddCTP, Biotin Labeled-5-Aminoallyl-ddCTP, Dye-Labeled-5-Aminoallyl-UTP, Biotin Labeled-5-Aminoallyl-UTP, Dye-Labeled-5-Aminoallyl-CTP, Biotin Labeled-5-Aminoallyl-CTP
  • Click Chemistry
      C8-A-dUTP, C8-A-dCTP, 5-E-UTP, 5-E-dUTP, EdU-488, EdU-555, EdU-594, EdU-647, EdU-FC-488, EdU-FC-555, EdU-FC-594, EdU- FC-647, EdU HTS Kit 488, EdU HTS Kit 555, EdU HTS Kit 594, EdU Click 488 Kit, EdU Click 555 Kit, EdU Click 594 Kit, EdU Click 647 Kit, EdU Flow Cytometry488, EdU Flow Cytometry555, EdU Flow Cytometry594, EdU Flow Cytometry647, EdU HTS488- 2x96 Kit, EdU HTS555- 2x96 Kit, EdU HTS594- 2x96 Kit, EdU HTS647- 2x96 Kit

Nucleoside Triphosphates in alphabetical order:

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