Nucleoside Triphosphate Synthesis

ChemCyte Inc. is a full-service nucleoside triphosphate manufacturer specializing in nucleoside triphosphate synthesis with over 100 natural and modified nucleoside triphosphates in stock. As a nucleoside triphosphate provider, ChemCyte manufactures a variety of non-modified and modified nucleoside triphosphates (nucleotides) and their analogs for life science, diagnostic and drug discovery research. ChemCyte specializes in nucleoside and nucleotide chemistry with special emphasis on labeled nucleotide for genomic research.

Nucleoside triphosphates and nucleotides have diverse biological properties. Modified and fluorescent-labeled nucleotide analogs provide sensitive probes for studying the structure, dynamics, and interactions of nucleic acids for biochemical research. In addition, nucleoside analogs have diverse therapeutic properties and have been used in medical treatments, including antiretroviral therapy regimens (for the treatment of HIV), anti-rejection therapy for organ transplants, hematological malignancy therapy, and the treatment of nonmalignant disorders, solid tumors, immunologic diseases, and multiple sclerosis.

We have quoted Wikipedia below since their description of Nucleoside Triphosaphate is excellent:

"A nucleoside triphosphate (NTP) is a molecule containing a nucleoside bound to three phosphates (also known as a nucleotide). Nucleotide derivatives are necessary for life, as they are the building blocks of nucleic acids and have thousands of other roles in cell metabolism and regulation. NTPs generally provide energy and phosphate group for phosphorylations.

Natural nucleoside triphosphates include adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP), 5-methyluridine triphosphate (m5UTP), and uridine triphosphate (UTP). ATP is a major source of cellular energy. GTP is a very frequent cofactor of enzymes and proteins.

The terms ATP, GTP, CTP, and UTP refer to those nucleoside triphosphates that contain ribose. The nucleoside triphosphates containing deoxyribose are called dNTPs, and take the prefix deoxy- in their names and small d- in their abbreviations: deoxyadenosine triphosphate (dATP), deoxyguanosine triphosphate (dGTP), deoxycytidine triphosphate (dCTP), deoxythymidine triphosphate (dTTP) and deoxyuridine triphosphate. The dNTPs are the building blocks for DNA (they lose two of the phosphate groups in the process of incorporation).

Apart from (d)ATP, (d)GTP, (d)CTP, (d)TTP and (d)UTP, there are other less abundant NTPs, such as intermediates of nucleotide metabolism, but also "rare" natural nucleotides or even artificial nucleotides.[1] An example of rare NTPs are the tautomeric forms of some NTPs.

Nucleoside Triphosphate Synthesis

Nucleoside Triphosphates currently in inventory and available for immediate shipment:

  • Non-Modified Nucleoside Triphosphates
  • Base Modified Nucleoside Triphosphates
      AA-dCTP, AA-dUTP, AA-CTP, AA-UTP, 8-Amino-ATP
  • Phosphate Modified Nucleoside Triphosphates
      Alpha-thio-dATP, Alpha-thio-dCTP, Alpha-thio-dGTP, Alpha-thio-TTP, Alpha-thio-ATP, Alpha-thio-CTP, Alpha-thio-GTP, Alpha-thio-UTP
  • Sugar Modified Nucleoside Triphosphates
      2-Fluoro-dCTP, 2-Fluoro-dUTP, ddATP, ddCTP, ddGTP, dTTP, ddUTP, 2'-O-Me-ATP, 2'-O-Me-CTP, 2'-O-Me-GTP, 2'-O-Me-UTP
  • Phosphate and Sugar Modified Nucleoside Triphosphates
      Alpha-thio-ddATP, Alpha-thio-ddCTP, Alpha-thio-ddGTP, Alpha-thio-dTTP
  • Biotin Nucleotide Analogs
      Biotin-5-dCTP, Biotin-11-dCTP, Biotin-16-dCTP, Biotin-5-dUTP, Biotin-11-dUTP, Biotin-16-dUTP, Biotin-5-CTP, Biotin-11-CTP, Biotin-16-CTP, Biotin-5-UTP, Biotin-11-UTP, Biotin-16-UTP
  • Cyanine Dye Nucleotide Analogs
      SulfoCyanine 3-dCTP, SulfoCyanine 3-dUTP, SulfoCyanine 5-dCTP, SulfoCyanine 5-dUTP, SulfoCyanine 3-CTP, SulfoCyanine 3-UTP, SulfoCyanine-5-CTP, SulfoCyanine-5-UTP
  • Antiviral Nucleotides
      3TCMP, 3TCTP, AzTMP, AzTTP, d4TMP, d4TTP, Ribavirin-5-triphosphate
  • Labeled Nucleoside Triphosphates
      Dye-Labeled-5-Aminoallyl-dUTP, Biotin Labeled-5-Aminoallyl-dUTP, Dye-Labeled-5-Aminoallyl-dCTP, Biotin Labeled-5-Aminoallyl-dCTP, Dye-Labeled-5-Aminoallyl-ddUTP, Biotin Labeled-5-Aminoallyl-ddUTP, Dye-Labeled-5-Aminoallyl-ddCTP, Biotin Labeled-5-Aminoallyl-ddCTP, Dye-Labeled-5-Aminoallyl-UTP, Biotin Labeled-5-Aminoallyl-UTP, Dye-Labeled-5-Aminoallyl-CTP, Biotin Labeled-5-Aminoallyl-CTP
  • Click Chemistry
      C8-A-dUTP, C8-A-dCTP, 5-E-UTP, 5-E-dUTP, EdU-488, EdU-555, EdU-594, EdU-647, EdU-FC-488, EdU-FC-555, EdU-FC-594, EdU- FC-647, EdU HTS Kit 488, EdU HTS Kit 555, EdU HTS Kit 594, EdU Click 488 Kit, EdU Click 555 Kit, EdU Click 594 Kit, EdU Click 647 Kit, EdU Flow Cytometry488, EdU Flow Cytometry555, EdU Flow Cytometry594, EdU Flow Cytometry647, EdU HTS488- 2x96 Kit, EdU HTS555- 2x96 Kit, EdU HTS594- 2x96 Kit, EdU HTS647- 2x96 Kit

Nucleoside Triphosphates in alphabetical order:

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